THE FUTURE OF HUMANITY IN THE ALIEN UNIVERSE

Okay, so we know that the Engineers are a galaxy-spanning people, and their influence extends beyond our one galaxy.
That said, it's a safe bet that the Engineers David bombed were just an isolated settlement, perhaps a colony established to support and supply the outpost on LV-223.

The differences in Engineer physical appearance can be easily explained by hypothesizing a Genetic-based Caste system. However, I am more inclined to whitewash the SfX budget limitations that gave rise to the 'different-looking' Engineers seen in ALIEN: Covenant and simply assume them to be the same as the ones seen in PROMETHEUS. Now, some points I am filling in by logic and assumption as movies are pretty hemmed-in by time and budget.

Humanity has mucked around on LV-223, and it's a safe assumption that some degree of automation like an alarm system or simple environmental monitoring-alert systems took note of the Prometheus crew's arrival and explorations, possibly sending a signal to the appropriate authorities in the Engineer Hegemony.
It's logical to assume this given how volatile the Pathogen is, and how much of it is kept on LV-223.
Some time later, one of their outlying colonies goes 'dark', and again we can presume some kind of automated catastrophe-alert system sent off a message. We have such things today in the real world and our technology is very primitive compared to the Engineers.

Also, having such in-place makes sense, same as it does on our world.

Sooner or later, the Engineers are going to be very invested in getting some answers, and they will likely consider themselves to be on a 'war' footing, however everything that has transpired thus far simply adds fuel to their reason and decision to exterminate Humanity, and hunt down David.
Humanity's future in the ALIEN universe must by definition involve a stand-up civilization- to-civilization contact with the Engineers and if Humanity thinks it can even begin to fight a war vs them, that's just absolute foolishness.

Humanity will have to accept any and all limitations imposed on it by the Engineers, or face extermination. If Humanity wants a future, it will have to fight, but do so very cleverly, and it will take generations as the Engineers are a truly vast enemy with all the advantages on their side. The only way Humanity can 'win' (survive) is by playing quiet, stealthy, clever strategies for generations until it has achieved the means to decapitate Engineer civilization in a single and annihilative stroke where the Engineers have no chance for a last-act deathblow.

What do you think?

This line of thought Inspired by this Thread and posts found on it:
Where we are at heading into the next instalment. (Some Novelisation content)